To C or not to C: these are the questions

To C or not to C: these are the questions in renal transplantation.

To C or not to C, that is the question!

Irrespective of the prevailing fashion, Germinal Centre Conferences (GCC) have treated the immune system in a determinedly holistic manner. At the recent 10th GCC* the advantages of this approach were demonstrated in elegant new schema for lymphocyte development, accessory cell function, tolerance and autoimmunity, and for the organization and function of mucosal defence. This report concentrat...

To Simulate or Not to Simulate: What Are the Questions?

Simulation is a powerful method in science and engineering. However, simulation is an umbrella term, and its meaning and goals differ among disciplines. Rapid advances in neuroscience and computing draw increasing attention to large-scale brain simulations. What is the meaning of simulation, and what should the method expect to achieve? We discuss the concept of simulation from an integrated sc...

To Flip or Not to Flip: What Are the Questions?

The flipped classroom has been receiving a lot of press lately as a more desirable way to manage the classroom and help students learn. However, flipping the classroom may not be appropriate for every course or every instructor. There may be a time when other active learning strategies are more appropriate to meet learning outcomes, student needs, and instructor capacity. This manuscript will d...

Acute hepatitis C: to treat or not to treat.

Although no randomized controlled trials have addressed this question, I recommend a 3to 6-month course of peginterferon-based therapy (with or without ribavirin) in those patients who have failed to clear acute infection. Success rates in this setting (ie, rates of sustained viral clearance) approach 90%. The importance of early treatment is clear: these success rates vastly eclipse those seen...